Interactions of CBD With Morphine

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CBD has rapidly become a popular area of medical study for several reasons. First, it does not produce a high in patients who use it. Second, it does not appear to cause any symptoms of chemical dependency. A low potential for abuse or addiction makes it highly promising.

Being that CBD has recently entered the medical mainstream, there are so many questions that needed to be researched and explored. There is so much that still needs to learned about CBD. Unfortunately, it will be a while before a “large enough patient community exists for a multi-decade CBD clinical study to be completed” (Policy Lab US).

Within the last few years, doctors have launched small-scale CBD studies and CBD clinical trials to find other potential uses for the compound. There have been promising CBD medical discoveries that show the possibility of CBD being useful for a wide range of conditions throughout life. As these studies and trials continue to take place, doctors will have a better understanding of how CBD affects the perception of pain. Resulting in safer and more effective doses in patients (Policy Lab US).

The most up to date CBD trials can be found on A recent trial taking place is “Phase 1 Drug-drug Interaction of Cannabidiol and Morphine in Recreational Opioid Users”, identifier # NCT05143424. This information is being provided by the National Institute on Drug Abuse (NIDA) and began on November 4, 2021, the estimated primary completion date is September 1, 2022 and/or the study completion date is December 1, 2022. This study has 60 participants, males and females, ranging from 18-55 years of age. The detailed description of this study is ” an inpatient, single-blind, non-randomized, 1-sequence study involving healthy subjects who have used opioids for recreational use. The primary objective of the study is to establish the pharmacokinetic parameters of morphine 30 mg when administered with and without CBD 350 mg b.i.d. and CBD 700 mg b.i.d.”  Participants will be given CBD twice per day for three days. This study is for “recreational opioid use (i.e., defined as prescription opioid use for nontherapeutic purposes on at least 3 occasions within the previous year and at least once in the 12 weeks prior to screening), experienced in using opioids of approximately 30 mg morphine equivalents and not seeking treatment for Opioid Use Disorder”( Clinical Trials.Gov).

We are looking forward to the results and knowledge that comes from this current trial. If you are interested in participating in clinical trials, it is important to talk with your doctor and family/friends for support. To learn more, you can contact the study research staff here.

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